Inflammatory bowel disease genetic association
نویسندگان
چکیده
منابع مشابه
Neonatal Presentation of Unremitting Inflammatory Bowel Disease
Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...
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To cite: Ewing IE, Josephides E, Galloway D, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2012008418 DESCRIPTION A 27-year-old Sudanese woman presented to the emergency department with a 1-week history of lumbar back pain radiating to the buttocks. There was no history of trauma, fever or weight loss. Medical history included ulcerative colitis, maintain...
متن کاملGenetic Predisposition and Inflammatory Bowel Disease
Published reports demonstrated finding of different susceptible mutant alleles in association with inflammatory bowel disease (CD/UC) in diseased individuals from different populations. It was then assumed that the existence of different associated mutant alleles in subjects with inflammatory bowel disease from different populations means different diseases. Whether this assumption is correct o...
متن کاملThe genetic jigsaw of inflammatory bowel disease.
Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Clinical experience, epidemiological studies, and molecular genetics have provided strong evidence that both genetic and environmental factors are important in disease pathogenesi...
متن کاملINFLAMMATORY BOWEL DISEASE Genetic polymorphisms in biotransformation enzymes in Crohn’s disease: association with microsomal epoxide hydrolase
Background: Mucosal biotransformation enzymes can modify toxic compounds in the gut. As chemical or oxidative stress may be involved in the aetiology of Crohn’s disease, genes encoding for enzymes involved in the prevention of such stress may be candidates for genetic susceptibility to Crohn’s disease. Aim: To assess the association of Crohn’s disease with genetic polymorphisms in cytochrome P4...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2012
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3379